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Cocktails, tablets, capsules, and individual purified formulations of protease inhibitors and phosphatase inhibitors designed to protect proteins from degradation during cell lysis and extraction.
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Specific fluorogenic substrate for collagenase-3 (MMP) with a kcat/Km value of 1.09 x 106 M-1s-1 (pH = 7.5, T = 25 °C, substrate concentrations: 0.7 and 1.4 µM (S<
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PhosSTOP tablets are a proprietary blend of phosphatase inhibitors, formulated as a ready-to-use tablet which dissolves quickly in aqueous solutions (buffers), including buffers containing formalin (for formalin fixation).
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MW 943.12 g/mol, Purity >99%. Competitive protein kinase G (PKG) inhibitor. Ki = 86 µM for PKG; Ki = 550 µM for PKA. Potential inhibitory activity in neuronal systems.
MW 398.3 Da, Purity >98%. Cell-permeable p53 inhibitor. Pifithrin-α (ab120478) analog and prodrug. Shows more potent antiapoptotic effects than pifithrin-α. Shows antiobesogenic and hepatoprotective effects in vivo. .
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An inhibitor of NEDD8-activating enzyme; inhibits NEDDylation of UBC12 in a cell-free assay using recombinant human NAE; selectively inhibits NEDDylation over SUMOylation and ubiquitination in A549 cells; inhibits the growth of A549 cells (GI50 = 5.5 µM); inhibits tumor growth in an AGS gastric adenocarcinoma mouse xenograft model at 60 mg/kg
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
RBPJ Inhibitor-1 (RIN1) is the first RBPJ inhibitor, which blocks the functional interaction of RBPJ with SHARP. It inhibits NOTCH-dependent tumor cell proliferation and is intended for research use only.
Blocks the functional interaction of RBPJ with SHARP
Inhibits NOTCH-dependent tumor cell proliferation
Inhibits the proliferation of hematologic cancer cell lines
Promotes skeletal muscle differentiation from C2C12 myoblasts
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